Patterns of Sponge Abundance Across a Gradient of Habitat Quality in the Wakatobi Marine National Park, Indonesia

Sponges are important components of reef communities worldwide, fulfilling a number of important functional roles. Habitat degradation caused by the loss of hard corals has the potential to cause increases in sponge abundance and percentage cover as they gain access to resources such as space and food. In this study we compared sponge densities and percentage cover at sites with varying hard coral cover in the Wakatobi Marine National Park, Indonesia (WMNP). We found significant differences in sponge densities at the study sites but no significant difference in sponge densities on different surface angles. Unexpectedly, we also found a weak positive correlation between coral cover and sponge density. This indicates that spatial competition is unlikely to be the most important factor determining sponge abundance in the WMNP. In contrast to sponge density data, we found that sponge percentage cover and hard coral cover were weakly negatively correlated, but found no significant difference in sponge percentage cover between the study sites. Finally, multivariate analysis of the benthic communities at the study sites indicated that while sites with higher coral cover were characterised by coral (proportionally), lower coral cover sites were characterised by algae and sponges. This suggests that although there was no significant difference in sponge percentage cover between the study sites conditions that led to the loss of hard coral at lower quality sites mean that these sites are characterised by sponges and algae rather than by any other groups of benthic organisms

Open University Learning Analytics dataset

Learning Analytics focuses on the collection and analysis of learners’ data to improve their learning experience by providing informed guidance and to optimise learning materials. To support the research in this area we have developed a dataset, containing data from courses presented at the Open University (OU). What makes the dataset unique is the fact that it contains demographic data together with aggregated clickstream data of students’ interactions in the Virtual Learning Environment (VLE). This enables the analysis of student behaviour, represented by their actions. The dataset contains the information about 22 courses, 32,593 students, their assessment results, and logs of their interactions with the VLE represented by daily summaries of student clicks (10,655,280 entries). The dataset is freely available at https://analyse.kmi.open.ac.uk/open_dataset under a CC-BY 4.0 license

“We cannot let this happen again”: reversing UK flood policy in response to the Somerset Levels floods, 2014

The Multiple Streams Framework offers a theoretical account of how policy proposals move from latent possibilities to becoming favored for implementation. We apply this framework in the context of the policy response to the 2013–2014 flooding of the Somerset Levels and Moors. Stakeholder interviews and analysis of news media coverage evidence the way in which a specific policy option that had fallen out of favor with the national Environment Agency – dredging – came to the fore and was eventually adopted during the period in which the conjunction of problem, policy, and political pressures came to a head. Local political activists mobilized a wider campaign with the help of social media and capitalized on national political sensitivities to successfully promote dredging. What is less clear is the longevity of the policy reversal, given funding constraints

RPGR-associated retinopathy: clinical features, molecular genetics, animal models and therapeutic options

Retinitis pigmentosa GTPase regulator (RPGR) gene sequence variants account for the vast majority of X linked retinitis pigmentosa (RP), which is one of the most severe forms of RP. Symptoms of nyctalopia typically begin in childhood, with increasing loss of peripheral visual field during teenage years, and progressive central visual loss during the second to fourth decade of life. There is however marked intrafamilial and interfamilial phenotypic heterogeneity in affected males and carrier females. There is now a far greater understanding of the range of phenotypes associated with variants in this gene; including rod-cone dystrophy, cone-rod dystrophy, cone dystrophy, macular dystrophy and non-ocular phenotypes. There are also increasingly established genotype-phenotype associations and structure-function correlations. RPGR is involved in ciliary function, with ciliary dysfunction now recognised as the mechanism underlying a large proportion of inherited retinal disease. There has been significant progress in identifying naturally occurring animal models and developing novel models to define the underlying disease mechanisms and to test gene replacement therapy, in addition to advances in human retinal imaging, culminating in completed and planned clinical trials. These significant developments will be discussed

Metabolic responses of a phototrophic sponge to sedimentation supports transitions to sponge-dominated reefs

Declines in coral abundance have been linked to increased sedimentation at many locations across the world and at some of these locations there have been subsequent increases in sponge abundance. These shifts appear counterintuitive as sponges are suspension feeders and many rely on photosymbionts for carbon. At a sedimented reef in Indonesia (Wakatobi) corals have declined and the photoautotrophic sponge Lamellodysidea herbacea is now abundant. We hypothesise that this is partly due to L. herbacea's ability to clear its tissues of high levels of settled-sediment and compensate for associated metabolic demands by altering its respiration rate. Negligible detrimental effects to sponge tissue were observed after treatments up to five times the sedimentation rate of the highly sedimented reef. Rapid sediment clearance occurred that was potentially aided by mucus production. Finally, high sediment exposure caused an immediate reduction in respiration rate, likely due to reduced pumping to prevent clogging, whereas sustained high sedimentation caused an increase in respiration rate, potentially due to the energetic cost of mucus production. Our study provides evidence that some sponges can tolerate environments that appear unsuitable to many corals and with increased sedimentation this acclimation may support further transitions to sponge dominated reefs in the future

Drawing Boundaries

In “On Drawing Lines on a Map” (1995), I suggested that the different ways we have of drawing lines on maps open up a new perspective on ontology, resting on a distinction between two sorts of boundaries: fiat and bona fide. “Fiat” means, roughly: human-demarcation-induced. “Bona fide” means, again roughly: a boundary constituted by some real physical discontinuity. I presented a general typology of boundaries based on this opposition and showed how it generates a corresponding typology of the different sorts of objects which boundaries determine or demarcate. In this paper, I describe how the theory of fiat boundaries has evolved since 1995, how it has been applied in areas such as property law and political geography, and how it is being used in contemporary work in formal and applied ontology, especially within the framework of Basic Formal Ontology

Bestrophinopathies: perspectives on clinical disease, Bestrophin-1 function and developing therapies

Bestrophinopathies are a group of clinically distinct inherited retinal dystrophies that typically affect the macular region, an area synonymous with central high acuity vision. This spectrum of disorders is caused by mutations in bestrophin1 (BEST1), a protein thought to act as a Ca2+-activated Cl- channel in the retinal pigment epithelium (RPE) of the eye. Although bestrophinopathies are rare, over 250 individual pathological mutations have been identified in the BEST1 gene, with many reported to have various clinical expressivity and incomplete penetrance. With no current clinical treatments available for patients with bestrophinopathies, understanding the role of BEST1 in cells and the pathological pathways underlying disease has become a priority. Induced pluripotent stem cell (iPSC) technology is helping to uncover disease mechanisms and develop treatments for RPE diseases, like bestrophinopathies. Here, we provide a comprehensive review of the pathophysiology of bestrophinopathies and highlight how patient-derived iPSC-RPE are being used to test new genomic therapies in vitro

Herschel/SPIRE observations of the dusty disk of NGC 4244

We present Herschel/SPIRE images at 250, 350, and 500 mu m of NGC 4244, a typical low-mass, disk-only and edge-on spiral galaxy. The dust disk is clumpy and shows signs of truncation at the break radius of the stellar disk. This disk coincides with the densest part of the Hi disk. We compare the spectral energy distribution (SED), including the new SPIRE fluxes, to 3D radiative transfer models; a smooth model disk and a clumpy model with embedded heating. Each model requires a very high value for the dust scale-length (h(d) = 2-5 h(*)), higher dust masses than previous models of NGC 4244 (M-d = 0.47-1.39 x 10(7) M-circle dot) and a face-on optical depth of tau(f.o.)(V) = 0.4-1.12, in agreement with previous disk opacity studies. The vertical scales of stars and dust are similar. The clumpy model much better mimics the general morphology in the sub-mm images and the general SED. The inferred gas-to-dust mass ratio is compatible with those of similar low-mass disks. The relatively large radial scale-length of the dust disk points to radial mixing of the dusty ISM within the stellar disk. The large vertical dust scale and the clumpy dust distribution of our SED model are both consistent with a scenario in which the vertical structure of the ISM is dictated by the balance of turbulence and self-gravity